Premier League Gameweek 21 Tips
It is Gameweek 21 of the 2025-26 Premier League season with 10 fixtures played over Tuesday, Wednesday and Thursday.
We have picked out four best bets for the midweek action including the contest at the Etihad Stadium, where Manchester City face Brighton.
Tip 1 - Brighton or draw double chance v Manchester City @ 2/1
Manchester City’s title hopes were dealt a blow with a 1-1 draw at the Etihad against Chelsea on Sunday and the Citizens may struggle to hit back when they host Brighton on Wednesday.
City did look threatening in attack at the weekend, but they were also vulnerable defensively and Pep Guardiola has a major headache when it comes to his backline.
Key defenders Josko Gvardiol and Ruben Dias have joined John Stones and Nico Gonzalez on the sidelines and the Citizens look short at the back and in midfield.
Brighton can take confidence from a dominant 2-0 victory over Burnley on Saturday and they have a strong recent record against City, winning two and drawing one of the last three meetings.
Tip 2 - Bournemouth to beat Tottenham @ 11/10
Enzo Maresca and Ruben Amorim have been high-profile managerial departures since the turn of the year and Tottenham boss Thomas Frank is facing a fight to avoid the same plight.
The Spurs supporters appear to have turned on the former Brentford boss with results and style of play not delivering on any expectations.
The north Londoners have won only three of their last 12 matches and Spurs put in another tepid display when only managing a 1-1 draw with Sunderland on home turf on Sunday.
It’s 11 Premier League matches without a victory for Bournemouth, but the performances have been far better than the results indicate and the Cherries ran league leaders Arsenal close in a 3-2 defeat at the Vitality on Saturday.
An effort close to that level will likely be enough to beat Spurs and Bournemouth can deliver the goods.
Tip 3 - Crystal Palace to beat Aston Villa @ 2/1
There could be a small shock in south London when Crystal Palace host in-from Aston Villa on Wednesday.
The Villans have won 12 of their last 13 matches in all competitions, and while that is an impressive record, there has been a fair amount of good fortune mixed in.
Villa could have been two, three of four goals down in the first-half of their 2-1 victory over Chelsea last month and nine of their last 10 victories have come by a single-goal margin.
Unai Emery’s men were crushed 4-1 by Arsenal, prior to Saturday’s 3-1 success against Nottingham Forest and Villa look a little too short at Palace.
The Eagles have been struggling for wins, but there wasn’t anything wrong with recent performances against Newcastle, Fulham and Tottenham.
Goalscoring has been the issue for the south Londoners, but they have hit 37 shots in their last three games and the arrival of forward Brennan Johnson should boost the attacking output of Oliver Glasner’s men.
Palace have lost only four of 14 games at Selhurst Park this term and they should once again be difficult to beat in south London.
Tip 4 - Over 2.5 goals in Arsenal v Liverpool @ 3/4
The final selection of Gameweek 21 comes when Arsenal host Liverpool at the Emirates on Thursday night.
Arsenal were a little tepid in their approach when losing 1-0 to the Reds at Anfield in the early part of the campaign, but there is little to fear from the Merseyside men on home turf.
Arne Slot’s side have won only eight of their last 21 matches, and while they are unbeaten in their last five Premier League games, those matches have come against Brighton, Tottenham, Wolves, Leeds and Fulham.
The Reds have conceded in seven of their last 10 top-flight games and those matches have come against lesser opponents than Arsenal.
The Gunners continue to pursue Liverpool’s Premier League title and Mikel Arteta’s men have scored 34 times in their last 14 games.
Arsenal have a plethora of attacking options, with Kai Havertz and Gabriel Jesus back from injury, and there could be plenty of goals in north London.
Odds correct at time of publication but subject to change
