NFL Week 4 Tips
Week 3 of the 2025 NFL season is in the books and there are still six teams with unbeaten records as we head into Week 4.
Buffalo Bills, Philadelphia Eagles, Tampa Bay Buccaneers, Indianapolis Colts, San Francisco 49ers and Los Angeles Chargers are all 3-0 and looking to make more progress this week.
The opening tie of Week 4 sees Seattle Seahawks travel to NFC West rivals, Arizona Cardinals, while there's a cracking tie on the cards as Kansas City Chiefs welcome Baltimore Ravens to Kansas on Sunday.
NFC North rivals Green Bay Packers and Detroit Lions, meet in the early hours of Monday morning, while two further fixtures take place on Monday, with New York Jets travelling to Miami Dolphins and Denver Broncos hosting Cincinnati Bengals.
Tip 1 - Seattle Seahawks moneyline @ 10/11
Seattle Seahawks vs Arizona Cardinals (Friday, 1:15am BST)
The Seahawks are building momentum after losing their opening game of the season 17-13 to NFC West rivals San Francisco 49ers.
Quarterback Sam Darnold has now found his rhythm and he faces a Cardinals defence that has struggled to sack the quarterback.
Seattle have won their last seven games against the Cards and they should improve on that record and take advantage of James Conner's injury.
Conner is set to sadly miss the rest of the season with a foot injury and Arizona are set to struggle on offence as a result.
Remember: BetMGM is paying out early when your team takes a 17-point lead, regardless of the final result. More information can be found here.
Tip 2 - Chicago Bears moneyline @ 10/11
Chicago Bears vs Las Vegas Raiders (Sunday, 9.25pm BST)
The Bears finally clicked into gear on Sunday as they beat Dallas Cowboys 31-14.
Caleb Williams has thrown for 505 yards and six touchdowns in his last two games and his improvements in the pocket have been impossible to ignore.
They face Las Vegas Raiders on the road, with Pete Carroll's team coming into the game on the back of two consecutive defeats.
They conceded 41 points to Washington Commanders and they may struggle to keep Williams and his receiver room quiet.
Tip 3 – Green Bay Packers -7 @ 10/11
Green Bay Packers vs Dallas Cowboys (Monday, 01:20am)
Dallas Cowboys have lost twice already this season and even their 40-37 win over New York Giants was in overtime.
Their defeat to the Bears was worrying as their secondary was carved open with ease and they lost wide receiver CeeDee Lamb to injury.
Green Bay are out for revenge after a poor showing against the Cleveland Browns, but they beat both the Lions and Commanders in the first two weeks.
The Cowboys are now without their best receiver and they have not been able to stop teams scoring points, so this looks like a foregone conclusion in a huge game in the NFC.
Tip 4 – Buffalo Bills -16.5 @ 9/10
New Orleans Saints vs Buffalo Bills (Sunday, 6pm BST)
The Bills have scored 30 points in every one of their three games so far and things are looking comfortable for Sean McDermott's men.
Sadly, the same cannot be said for New Orleans Saints, who were planning for the 2026 season the minute Derek Carr announced his retirement in the offseason.
The Saints have conceded 20 points or more to the Cardinals, 49ers and Seahawks and they have shown little on offence to trouble the Bills.
Buffalo should suffocate them at home from the first whistle and this game could be over by half-time.
New Orleans may score a touchdown or two in garbage time, but expect Josh Allen and co to be out of site by then.
Odds correct at time of publication but subject to change
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